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Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort

Aleksandrova, Krasimira , Jenab, Mazda, Leitzmann, Michael, Bueno-de-Mesquita, Bas, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Rinaldi, Sabina, Freisling, Heinz, Carayol, Marion , Pischon, Tobias , Drogan, Dagmar, Weiderpass, Elisabete , Jakszyn, Paula, Overvad, Kim, Dahm, Christina C , Tjønneland, Anne , Bouton-Ruault, Marie-Christine, Kühn, Tilman, Peppa, Eleni, Valanou, Elissavet , La Vecchia, Carlo , Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Agnoli, Claudia , Tumino, Rosario, May, Anne, van Vulpen, Jonna, Benjaminsen Borch, Kristin, Oluwafemi Oyeyemi, Sunday, Quirós, J Ramón, Bonet, Catalina, Sánchez, María-José, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, van Guelpen, Bethany, Wennberg, Patrik, Key, Timothy J, Khaw, Kay-Tee, Wareham, Nicholas, Assi, Nada, Ward, Heather A, Aune, Dagfinn , Riboli, Elio and Boeing, Heiner (2017) Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort. International Journal of Epidemiology 46 (6), pp. 1823-1835.

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Other URL: http://doi.org/10.1093/ije/dyx174


Abstract

There is convincing evidence that high physical activity lowers the risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We aimed to determine the extent to which body fatness and biomarkers of various biologically plausible pathways account for the association between physical activity and colon cancer. We conducted a nested case-control study in a cohort ...

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Item type:Article
Date:2017
Institutions:Medicine > Institut für Epidemiologie und Präventivmedizin
Identification Number:
ValueType
10.1093/ije/dyx174DOI
Keywords:SOLUBLE LEPTIN RECEPTOR; COLORECTAL-CANCER; VITAMIN-D; METABOLIC SYNDROME; NUTRITION COHORT; CONTROLLED-TRIAL; RECTAL CANCERS; SERUM-LEVELS; WEIGHT-LOSS; METAANALYSIS; Physical activity; colon cancer; mediating factors; adiposity; biomarkers
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39500
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