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Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort

Aleksandrova, Krasimira ; Jenab, Mazda ; Leitzmann, Michael ; Bueno-de-Mesquita, Bas ; Kaaks, Rudolf ; Trichopoulou, Antonia ; Bamia, Christina ; Lagiou, Pagona ; Rinaldi, Sabina ; Freisling, Heinz ; Carayol, Marion ; Pischon, Tobias ; Drogan, Dagmar ; Weiderpass, Elisabete ; Jakszyn, Paula ; Overvad, Kim ; Dahm, Christina C. ; Tjønneland, Anne ; Bouton-Ruault, Marie-Christine ; Kühn, Tilman ; Peppa, Eleni ; Valanou, Elissavet ; La Vecchia, Carlo ; Palli, Domenico ; Panico, Salvatore ; Sacerdote, Carlotta ; Agnoli, Claudia ; Tumino, Rosario ; May, Anne ; van Vulpen, Jonna ; Benjaminsen Borch, Kristin ; Oluwafemi Oyeyemi, Sunday ; Quirós, J. Ramón ; Bonet, Catalina ; Sánchez, María-José ; Dorronsoro, Miren ; Navarro, Carmen ; Barricarte, Aurelio ; van Guelpen, Bethany ; Wennberg, Patrik ; Key, Timothy J. ; Khaw, Kay-Tee ; Wareham, Nicholas ; Assi, Nada ; Ward, Heather A. ; Aune, Dagfinn ; Riboli, Elio ; Boeing, Heiner



Abstract

There is convincing evidence that high physical activity lowers the risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We aimed to determine the extent to which body fatness and biomarkers of various biologically plausible pathways account for the association between physical activity and colon cancer. We conducted a nested case-control study in a cohort ...

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