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HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization

Fan, Qiao, Maranville, Joseph C, Fritsche, Lars , Sim, Xueling, Cheung, Chui Ming Gemmy, Chen, Li Jia, Gorski, Mathias, Yamashiro, Kenji , Ahn, Jeeyun, Laude, Augustinus, Dorajoo, Rajkumar, Lim, Tock Han, Teo, Yik-Ying, Blaustein, Robert O, Yoshimura, Nagahisa, Park, Kyu-Hyung, Pang, Chi Pui, Tai, E Shyong, Khor, Chiea Chuen, Wong, Tien Yin, Runz, Heiko and Cheng, Ching-Yu (2017) HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization. International Journal of Epidemiology 46 (6), pp. 1891-1902.

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Other URL: http://doi.org/10.1093/ije/dyx189


Abstract

Dyslipidemia, particularly high-density lipoprotein cholesterol (HDL-C), has recently been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of vision loss. However, epidemiological studies have yielded conflicting results. We investigated the causal role of plasma lipid levels in AMD in multiethnic populations comprising 16 144 advanced AMD cases and 17 ...

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Item type:Article
Date:2017
Institutions:Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie
Identification Number:
ValueType
10.1093/ije/dyx189DOI
Keywords:HIGH-DENSITY-LIPOPROTEIN; POLYPOIDAL CHOROIDAL VASCULOPATHY; CORONARY-ARTERY-DISEASE; GENOME-WIDE ASSOCIATION; SERUM-LIPOPROTEIN; COMMON VARIANTS; EYE; SUSCEPTIBILITY; MACULOPATHY; LOCI; HDL-cholesterol; AMD; lipids; Mendelian randomization; genetic association
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39501
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