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HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization

Fan, Qiao ; Maranville, Joseph C. ; Fritsche, Lars ; Sim, Xueling ; Cheung, Chui Ming Gemmy ; Chen, Li Jia ; Gorski, Mathias ; Yamashiro, Kenji ; Ahn, Jeeyun ; Laude, Augustinus ; Dorajoo, Rajkumar ; Lim, Tock Han ; Teo, Yik-Ying ; Blaustein, Robert O. ; Yoshimura, Nagahisa ; Park, Kyu-Hyung ; Pang, Chi Pui ; Tai, E. Shyong ; Khor, Chiea Chuen ; Wong, Tien Yin ; Runz, Heiko ; Cheng, Ching-Yu


Dyslipidemia, particularly high-density lipoprotein cholesterol (HDL-C), has recently been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of vision loss. However, epidemiological studies have yielded conflicting results. We investigated the causal role of plasma lipid levels in AMD in multiethnic populations comprising 16 144 advanced AMD cases and 17 ...


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