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Ageing sensitized by iPLA 2 β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids

Jiao, Li, Gan-Schreier, Hongying, Zhu, Xingya, Wei, Wang, Tuma-Kellner, Sabine, Liebisch, Gerhard , Stremmel, Wolfgang and Chamulitrat, Walee (2017) Ageing sensitized by iPLA 2 β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1862 (12), pp. 1520-1533.

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Other URL: http://doi.org/10.1016/j.bbalip.2017.09.001


Abstract

Ageing is a major risk factor for various forms of liver and gastrointestinal (GI) disease and genetic background may contribute to the pathogenesis of these diseases. Group VIA phospholipase A2 or iPLA(2)beta is a homeostatic PLA2 by playing a role in phospholipid metabolism and remodeling. Global iPLA(2)beta(-/-) mice exhibit aged-dependent phenotypes with body weight loss and abnormalities in ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin
Identification Number:
ValueType
10.1016/j.bbalip.2017.09.001DOI
Keywords:INDEPENDENT PHOSPHOLIPASE A(2); ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; INFLAMMATORY-BOWEL-DISEASE; NUCLEAR HORMONE-RECEPTORS; FACTOR 1-ALPHA HNF1-ALPHA; OXIDATIVE STRESS; ER STRESS; HEPATIC STEATOSIS; APOPTOTIC CELLS; P1a2G6; Ageing; Intestinal homeostasis; XBP1; Lipidomics; FXR
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39542
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