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Ageing sensitized by iPLA 2 β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids

Jiao, Li ; Gan-Schreier, Hongying ; Zhu, Xingya ; Wei, Wang ; Tuma-Kellner, Sabine ; Liebisch, Gerhard ; Stremmel, Wolfgang ; Chamulitrat, Walee


Ageing is a major risk factor for various forms of liver and gastrointestinal (GI) disease and genetic background may contribute to the pathogenesis of these diseases. Group VIA phospholipase A2 or iPLA(2)beta is a homeostatic PLA2 by playing a role in phospholipid metabolism and remodeling. Global iPLA(2)beta(-/-) mice exhibit aged-dependent phenotypes with body weight loss and abnormalities in ...


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