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Prefrontal transcranial direct current stimulation (tDCS) as treatment for major depression: study design and methodology of a multicenter triple blind randomized placebo controlled trial (DepressionDC)

Padberg, Frank ; Kumpf, Ulrike ; Mansmann, Ulrich ; Palm, Ulrich ; Plewnia, Christian ; Langguth, Berthold ; Zwanzger, Peter ; Fallgatter, Andreas ; Nolden, Jana ; Burger, Max ; Keeser, Daniel ; Rupprecht, Rainer ; Falkai, Peter ; Hasan, Alkomiet ; Egert, Silvia ; Bajbouj, Malek


Transcranial direct current stimulation (tDCS) has been proposed as novel treatment for major depressive disorder (MDD) based on clinical pilot studies as well as randomized controlled monocentric trials. The DepressionDC trial is a triple-blind (blinding of rater, operator and patient), randomized, placebo controlled multicenter trial investigating the efficacy and safety of prefrontal tDCS used ...


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