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Chronic Inflammation Increases the Sensitivity of Mouse Treg for TNFR2 Costimulation

Schmid, Tobias ; Falter, Lena ; Weber, Sabine ; Müller, Nils ; Molitor, Konstantin ; Zeller, David ; Weber-Steffens, Dorothea ; Hehlgans, Thomas ; Wajant, Harald ; Mostböck, Sven ; Männel, Daniela N.



Abstract

TNF receptor type 2 (TNFR2) has gained attention as a costimulatory receptor for T cells and as critical factor for the development of regulatory T cells (Treg) and myeloid suppressor cells. Using the TNFR2-specific agonist TNCscTNF80, direct effects of TNFR2 activation on myeloid cells and T cells were investigated in mice. In vitro, TNCscTNF80 induced T cell proliferation in a costimulatory ...

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