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Chronic Inflammation Increases the Sensitivity of Mouse Treg for TNFR2 Costimulation

Schmid, Tobias, Falter, Lena, Weber, Sabine, Müller, Nils, Molitor, Konstantin, Zeller, David, Weber-Steffens, Dorothea, Hehlgans, Thomas, Wajant, Harald, Mostböck, Sven and Männel, Daniela N. (2017) Chronic Inflammation Increases the Sensitivity of Mouse Treg for TNFR2 Costimulation. Frontiers in Immunology 8.

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Other URL: http://doi.org/10.3389/fimmu.2017.01471

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

TNF receptor type 2 (TNFR2) has gained attention as a costimulatory receptor for T cells and as critical factor for the development of regulatory T cells (Treg) and myeloid suppressor cells. Using the TNFR2-specific agonist TNCscTNF80, direct effects of TNFR2 activation on myeloid cells and T cells were investigated in mice. In vitro, TNCscTNF80 induced T cell proliferation in a costimulatory ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Immunologie
Medicine > Regensburger Centrum für Interventionelle Immunologie (RCI)
Identification Number:
ValueType
10.3389/fimmu.2017.01471DOI
Keywords:TUMOR-NECROSIS-FACTOR; REGULATORY T-CELLS; SUPPRESSIVE ACTIVITY; RHEUMATOID-ARTHRITIS; AUTOIMMUNE-DISEASES; DENDRITIC CELLS; RECEPTOR; EXPANSION; EXPRESSION; MICE; inflammation; immune regulation; costimulation; MDSC; TNFR2; regulatory T cell
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39582
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