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Light-activated phenalen-1-one bactericides: efficacy, toxicity and mechanism compared with benzalkonium chloride

Muehler, Denise, Sommer, Kerstin, Wennige, Sara, Hiller, Karl-Anton, Cieplik, Fabian , Maisch, Tim and Späth, Andreas (2017) Light-activated phenalen-1-one bactericides: efficacy, toxicity and mechanism compared with benzalkonium chloride. Future Microbiology 12 (14), pp. 1297-1310.

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Other URL: http://doi.org/10.2217/fmb-2016-0229


Abstract

Aim: Five photoactive compounds with variable elongated alkyl-substituents in a phenalen-1-one structure were examined in view of structural similarity to the antimicrobial agent benzalkonium chloride (BAC). Methods: All phenalen-1-ones and BAC were evaluated for their antimicrobial properties against Staphylococcus aureus, methicillin-resistant S. aureus, Escherichia coli, Pseudomonas aeruginosa ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Dermatologie und Venerologie
Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie > Dr. rer. nat. Karl-Anton Hiller
Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Identification Number:
ValueType
10.2217/fmb-2016-0229DOI
Keywords:QUATERNARY AMMONIUM-COMPOUNDS; ANTIMICROBIAL PHOTODYNAMIC THERAPY; SOLID-PHASE EXTRACTION; ORAL KEY PATHOGENS; IN-VITRO; PSEUDOMONAS-AERUGINOSA; ALLERGIC REACTIONS; ESCHERICHIA-COLI; SINGLET OXYGEN; RESISTANCE; antimicrobial; benzalkonium chloride; Escherichia coli; NHEK; phenalen-1-one; photodynamic; SAPYR; singlet oxygen
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39601
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