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Light-activated phenalen-1-one bactericides: efficacy, toxicity and mechanism compared with benzalkonium chloride

Muehler, Denise ; Sommer, Kerstin ; Wennige, Sara ; Hiller, Karl-Anton ; Cieplik, Fabian ; Maisch, Tim ; Späth, Andreas


Aim: Five photoactive compounds with variable elongated alkyl-substituents in a phenalen-1-one structure were examined in view of structural similarity to the antimicrobial agent benzalkonium chloride (BAC). Methods: All phenalen-1-ones and BAC were evaluated for their antimicrobial properties against Staphylococcus aureus, methicillin-resistant S. aureus, Escherichia coli, Pseudomonas aeruginosa ...


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