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Sex-dependent differences in the in vivo respiratory phenotype of the TASK-1 potassium channel knockout mouse

Jungbauer, Stefan, Buehler, Philipp Karl , Neubauer, Jacqueline , Haas, Cordula , Heitzmann, Dirk, Tegtmeier, Ines, Sterner, Christina, Barhanin, Jacques, Georgieff, Michael, Warth, Richard and Thomas, Jörg (2017) Sex-dependent differences in the in vivo respiratory phenotype of the TASK-1 potassium channel knockout mouse. Respiratory Physiology & Neurobiology 245, pp. 13-28.

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Other URL: http://doi.org/10.1016/j.resp.2016.11.005


Abstract

TASK-1 potassium channels have been implicated in central and peripheral chemoreception; however, the precise contribution of TASK-1 for the control of respiration is still under debate. Here, we investigated the respiration of unrestrained adult and neonatal TASK-1 knockout mice (TASK-1(-/-)) using a plethysmographic device. Respiration in adult female TASK-1(-/-) mice under control (21% O-2), ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Physiologie
Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Richard Warth
Identification Number:
ValueType
10.1016/j.resp.2016.11.005DOI
Keywords:INFANT-DEATH-SYNDROME; PULMONARY ARTERIAL-HYPERTENSION; DOMAIN K+ CHANNEL; CAROTID-BODY; VENTILATORY RESPONSES; BRAIN-STEM; INHALATION ANESTHETICS; CHEMORECEPTOR NEURONS; PH SENSITIVITY; GLOMUS CELLS; TASK-1 channel; Whole body plethysmograph; Sex-dependent; Chemoreception; Neonatal mice
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39621
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