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Sex-dependent differences in the in vivo respiratory phenotype of the TASK-1 potassium channel knockout mouse

Jungbauer, Stefan ; Buehler, Philipp Karl ; Neubauer, Jacqueline ; Haas, Cordula ; Heitzmann, Dirk ; Tegtmeier, Ines ; Sterner, Christina ; Barhanin, Jacques ; Georgieff, Michael ; Warth, Richard ; Thomas, Jörg



Abstract

TASK-1 potassium channels have been implicated in central and peripheral chemoreception; however, the precise contribution of TASK-1 for the control of respiration is still under debate. Here, we investigated the respiration of unrestrained adult and neonatal TASK-1 knockout mice (TASK-1(-/-)) using a plethysmographic device. Respiration in adult female TASK-1(-/-) mice under control (21% O-2), ...

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