; Graf, Erika ; Koller, Michael ; Kleinjung, Tobias ; Lehner, Astrid ; Schecklmann, Martin ; Pöppl, Timm B. ; Kreuzer, Peter ; Frank, Elmar ; Langguth, Berthold | Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Brain Stimulation | ||||
| Publisher: | Elsevier | ||||
| Place of Publication: | NEW YORK | ||||
| Volume: | 10 | ||||
| Number of Issue or Book Chapter: | 6 | ||||
| Page Range: | pp. 1112-1120 | ||||
| Date: | 2017 | ||||
| Institutions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien | ||||
| Identification Number: |
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| Keywords: | TRANSCRANIAL MAGNETIC STIMULATION; POSITRON-EMISSION-TOMOGRAPHY; AUDITORY-CORTEX; TEMPOROPARIETAL JUNCTION; MAJOR DEPRESSION; EFFICACY; SAFETY; PLASTICITY; INVENTORY; NETWORK; Tinnitus; Repetitive transcranial magnetic stimulation; Auditory phantom perception; RCT; Evidence-based psychiatry; Neurostimulation | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 39628 |
Abstract
Background: Chronic tinnitus is a frequent, difficult to treat disease with high morbidity. Objective: This multicenter randomized, sham-controlled trial investigated the efficacy and safety of 1-Hz repetitive transcranial magnetic stimulation (rTMS) applied to the left temporal cortex in patients with chronic tinnitus. Methods: Tinnitus patients were randomized to receive 10 sessions of either ...

Abstract
Background: Chronic tinnitus is a frequent, difficult to treat disease with high morbidity. Objective: This multicenter randomized, sham-controlled trial investigated the efficacy and safety of 1-Hz repetitive transcranial magnetic stimulation (rTMS) applied to the left temporal cortex in patients with chronic tinnitus. Methods: Tinnitus patients were randomized to receive 10 sessions of either real or sham 1-Hz-rTMS (2000 stimuli, 110% motor threshold) to the left temporal cortex. The primary outcome was the change in the sum score of the tinnitus questionnaire (TQ) of Goebel and Hiller from baseline to end of treatment. Results: A total of 163 patients were enrolled in the study (real rTMS: 75; sham rTMS: 78). At day 12, the baseline mean of 43.1 TQ points in 71 patients assigned to real rTMS changed by -0.5 points; it changed by 0.5 points from a baseline of 42.1 in 75 patients randomized to sham rTMS (adjusted mean difference between groups: -1.0; 95.19% confidence interval: -3.2 to 1.2; p = 0.36). All secondary outcome measures including measures of depression and quality of life showed no significant differences either (p > 0.11). The number of participants with side-effects or adverse events did not differ between groups. Conclusion: Real 1-Hz-rTMS over the left temporal cortex was well tolerated but not superior compared with sham rTMS in improving tinnitus severity. These findings are in contrast to results from studies with smaller sample sizes and put the efficacy of this rTMS protocol for treatment of chronic tinnitus into question. (C) 2017 Elsevier Inc. All rights reserved.
Metadata last modified: 25 Nov 2020 15:47
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