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C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation

Burel, Sophie ; Coyan, Fabien C. ; Lorenzini, Maxime ; Meyer, Matthew R. ; Lichti, Cheryl F. ; Brown, Joan H. ; Loussouarn, Gildas ; Charpentier, Flavien ; Nerbonne, Jeanne M. ; Townsend, R. Reid ; Maier, Lars S. ; Marionneau, Céline



Abstract

Voltage-gated Na+ (Na-V) channels are key regulators of myocardial excitability, and Ca2+/calmodulin-dependent protein kinase II (CaMKII)-dependent alterations in Na(V)1.5 channel inactivation are emerging as a critical determinant of arrhythmias in heart failure. However, the global native phosphorylation pattern of Na(V)1.5 subunits associated with these arrhythmogenic disorders and the ...

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