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Cationic nioplexes-in-polysaccharide-based hydrogels as versatile biodegradable hybrid materials to deliver nucleic acids

Grijalvo, Santiago ; Alagia, Adele ; Puras, Gustavo ; Zárate, Jon ; Mayr, Judith ; Pedraz, Jose Luis ; Eritja, Ramon ; Díaz, David Díaz


Two polysaccharide-based hydrogels made of only k-carrageenan (4%; w/v) or of a mixture of methylcellulose: k-carrageenan (2%; w/v) were used to encapsulate cationic nioplexes. These vesicular particles were made of a synthetic aminolipid and polysorbate-80 (Tween-80), as a non-ionic surfactant agent. According to oscillatory rheological measurements, the presence of nioplexes did not compromise ...


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