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Cationic nioplexes-in-polysaccharide-based hydrogels as versatile biodegradable hybrid materials to deliver nucleic acids

Grijalvo, Santiago , Alagia, Adele, Puras, Gustavo, Zárate, Jon, Mayr, Judith, Pedraz, José Luis, Eritja, Ramon and Díaz, David Díaz (2017) Cationic nioplexes-in-polysaccharide-based hydrogels as versatile biodegradable hybrid materials to deliver nucleic acids. Journal of Materials Chemistry B 5 (37), pp. 7756-7767.

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Other URL: http://doi.org/10.1039/c7tb01691c


Abstract

Two polysaccharide-based hydrogels made of only k-carrageenan (4%; w/v) or of a mixture of methylcellulose: k-carrageenan (2%; w/v) were used to encapsulate cationic nioplexes. These vesicular particles were made of a synthetic aminolipid and polysorbate-80 (Tween-80), as a non-ionic surfactant agent. According to oscillatory rheological measurements, the presence of nioplexes did not compromise ...

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Item type:Article
Date:2017
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. David Díaz Díaz
Identification Number:
ValueType
10.1039/c7tb01691cDOI
Keywords:BIOMEDICAL APPLICATIONS; DRUG-DELIVERY; GENE DELIVERY; ANTISENSE OLIGONUCLEOTIDES; NONIONIC SURFACTANT; VESICLES NIOSOMES; KAPPA-CARRAGEENAN; RELEASE; METHYLCELLULOSE; RNA;
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39679
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