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Evolutionary diversification of protein–protein interactions by interface add-ons

Plach, Maximilian G. ; Semmelmann, Florian ; Busch, Florian ; Busch, Markus ; Heizinger, Leonhard ; Wysocki, Vicki H. ; Merkl, Rainer ; Sterner, Reinhard


Cells contain amultitude of protein complexes whose subunits interact with high specificity. However, the number of different protein folds and interface geometries found in nature is limited. This raises the question of how protein-protein interaction specificity is achieved on the structural level and how the formation of nonphysiological complexes is avoided. Here, we describe structural ...


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