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Evolutionary diversification of protein–protein interactions by interface add-ons

Plach, Maximilian G., Semmelmann, Florian, Busch, Florian, Busch, Markus, Heizinger, Leonhard, Wysocki, Vicki H. , Merkl, Rainer and Sterner, Reinhard (2017) Evolutionary diversification of protein–protein interactions by interface add-ons. Proceedings of the National Academy of Sciences 114 (40), E8333-E8342.

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Other URL: http://doi.org/10.1073/pnas.1707335114


Abstract

Cells contain amultitude of protein complexes whose subunits interact with high specificity. However, the number of different protein folds and interface geometries found in nature is limited. This raises the question of how protein-protein interaction specificity is achieved on the structural level and how the formation of nonphysiological complexes is avoided. Here, we describe structural ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie
Identification Number:
ValueType
10.1073/pnas.1707335114DOI
Keywords:BACILLUS-SUBTILIS; TRYPTOPHAN BIOSYNTHESIS; INTERACTION SPECIFICITY; ANTHRANILATE SYNTHASE; FOLIC-ACID; DOMAIN; SIGNAL; GENE; AMIDOTRANSFERASE; ARCHAEBACTERIA; protein-protein interactions; protein interfaces; interface add-on; glutamine amidotransferases; protein evolution
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39688
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