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GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder

Deckert, J. ; Weber, H. ; Villmann, C. ; Lonsdorf, T. B. ; Richter, J. ; Andreatta, M. ; Arias-Vasquez, A. ; Hommers, L. ; Kent, L. ; Schartner, C. ; Cichon, S. ; Wolf, C. ; Schaefer, N. ; von Collenberg, C. R. ; Wachter, B. ; Blum, R. ; Schümann, D. ; Scharfenort, R. ; Schumacher, J. ; Forstner, A. J. ; Baumann, C. ; Schiele, M. A. ; Notzon, S. ; Zwanzger, P. ; Janzing, J. G. E. ; Galesloot, T. ; Kiemeney, L. A. ; Gajewska, A. ; Glotzbach-Schoon, E. ; Mühlberger, A. ; Alpers, G. ; Fydrich, T. ; Fehm, L. ; Gerlach, A. L. ; Kircher, T. ; Lang, T. ; Ströhle, A. ; Arolt, V. ; Wittchen, H.-U. ; Kalisch, R. ; Büchel, C. ; Hamm, A. ; Nöthen, M. M. ; Romanos, M. ; Domschke, K. ; Pauli, P. ; Reif, A.



Abstract

The molecular genetics of panic disorder (PD) with and without agoraphobia (AG) are still largely unknown and progress is hampered by small sample sizes. We therefore performed a genome-wide association study with a dimensional, PD/AG-related anxiety phenotype based on the Agoraphobia Cognition Questionnaire (ACQ) in a sample of 1370 healthy German volunteers of the CRC TRR58 MEGA study wave 1. A ...

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