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GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder

Deckert, J, Weber, H, Villmann, C, Lonsdorf, T B, Richter, J, Andreatta, M, Arias-Vasquez, A, Hommers, L, Kent, L, Schartner, C, Cichon, S , Wolf, C, Schaefer, N, von Collenberg, C R, Wachter, B, Blum, R , Schümann, D, Scharfenort, R, Schumacher, J, Forstner, A J, Baumann, C, Schiele, M A, Notzon, S, Zwanzger, P, Janzing, J G E, Galesloot, T, Kiemeney, L A , Gajewska, A, Glotzbach-Schoon, E, Mühlberger, A, Alpers, G, Fydrich, T, Fehm, L, Gerlach, A L , Kircher, T , Lang, T, Ströhle, A, Arolt, V, Wittchen, H-U, Kalisch, R, Büchel, C, Hamm, A, Nöthen, M M, Romanos, M, Domschke, K, Pauli, P and Reif, A (2017) GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder. Molecular Psychiatry 22 (10), pp. 1431-1439.

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Other URL: http://doi.org/10.1038/mp.2017.2


Abstract

The molecular genetics of panic disorder (PD) with and without agoraphobia (AG) are still largely unknown and progress is hampered by small sample sizes. We therefore performed a genome-wide association study with a dimensional, PD/AG-related anxiety phenotype based on the Agoraphobia Cognition Questionnaire (ACQ) in a sample of 1370 healthy German volunteers of the CRC TRR58 MEGA study wave 1. A ...

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Item type:Article
Date:2017
Institutions:Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange
Identification Number:
ValueType
10.1038/mp.2017.2DOI
Keywords:GENOME-WIDE ASSOCIATION; GLYCINE RECEPTOR; ELEMENT INSERTION; MONOAMINE-OXIDASE; SPASTIC MOUSE; GENE; ANXIETY; POLYMORPHISM; METAANALYSIS; LOCUS;
Dewey Decimal Classification:100 Philosophy & psychology > 150 Psychology
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39743
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