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Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues

Delacher, Michael, Imbusch, Charles D, Weichenhan, Dieter, Breiling, Achim , Hotz-Wagenblatt, Agnes , Träger, Ulrike, Hofer, Ann-Cathrin, Kägebein, Danny, Wang, Qi, Frauhammer, Felix, Mallm, Jan-Philipp, Bauer, Katharina, Herrmann, Carl , Lang, Philipp A, Brors, Benedikt , Plass, Christoph and Feuerer, Markus (2017) Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues. Nature Immunology 18 (10), pp. 1160-1172.

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Other URL: http://doi.org/10.1038/ni.3799


Abstract

Regulatory T cells (T-reg cells) perform two distinct functions: they maintain self-tolerance, and they support organ homeostasis by differentiating into specialized tissue T-reg cells. We found that epigenetic modifications defined the molecular characteristics of tissue T-reg cells. Tagmentation-based whole-genome bisulfite sequencing revealed more than 11,000 regions that were methylated ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Immunologie
Medicine > Regensburger Centrum für Interventionelle Immunologie (RCI)
Identification Number:
ValueType
10.1038/ni.3799DOI
Keywords:TRANSCRIPTION FACTOR OCCUPANCY; ADIPOSE-TISSUE; CANNABINOID RECEPTOR; READ ALIGNMENT; IMMUNE-SYSTEM; INFLAMMATION; MACROPHAGE; POPULATION; VISUALIZATION; ACCUMULATION;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39744
Owner only: item control page
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