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Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues

Delacher, Michael ; Imbusch, Charles D. ; Weichenhan, Dieter ; Breiling, Achim ; Hotz-Wagenblatt, Agnes ; Träger, Ulrike ; Hofer, Ann-Cathrin ; Kägebein, Danny ; Wang, Qi ; Frauhammer, Felix ; Mallm, Jan-Philipp ; Bauer, Katharina ; Herrmann, Carl ; Lang, Philipp A. ; Brors, Benedikt ; Plass, Christoph ; Feuerer, Markus


Regulatory T cells (T-reg cells) perform two distinct functions: they maintain self-tolerance, and they support organ homeostasis by differentiating into specialized tissue T-reg cells. We found that epigenetic modifications defined the molecular characteristics of tissue T-reg cells. Tagmentation-based whole-genome bisulfite sequencing revealed more than 11,000 regions that were methylated ...


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