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Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice

Buehler, Philipp K., Bleiler, Doris, Tegtmeier, Ines, Heitzmann, Dirk, Both, Christian, Georgieff, Michael, Lesage, Florian , Warth, Richard and Thomas, Jörg (2017) Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice. Respiratory Physiology & Neurobiology 244, pp. 17-25.

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Other URL: http://doi.org/10.1016/j.resp.2017.06.009


Abstract

Despite intensive research, the exact function of TASK potassium channels in central and peripheral chemoreception is still under debate. In this study, we investigated the respiration of unrestrained TASK-3 (TASK-3(-/-)) and TASK-1/TASK-3 double knockout (TASK-1/3(-/-)) adult male mice in vivo using a plethysmographic device. Ventilation parameters of TASK-3/mice were normal under control ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Anästhesiologie
Biology, Preclinical Medicine > Institut für Physiologie
Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Richard Warth
Identification Number:
ValueType
10.1016/j.resp.2017.06.009DOI
Keywords:CEREBELLAR GRANULE NEURONS; DOMAIN K+ CHANNEL; CAROTID-BODY; ARTERIAL CHEMORECEPTORS; INHALATION ANESTHETICS; VENTILATORY RESPONSES; PH SENSITIVITY; GLOMUS CELLS; OXYGEN; CO2; TASK potassium channels; Chemoreception; Whole body plethysmograph; Hyperoxia
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39758
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