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Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice

Buehler, Philipp K. ; Bleiler, Doris ; Tegtmeier, Ines ; Heitzmann, Dirk ; Both, Christian ; Georgieff, Michael ; Lesage, Florian ; Warth, Richard ; Thomas, Jörg


Despite intensive research, the exact function of TASK potassium channels in central and peripheral chemoreception is still under debate. In this study, we investigated the respiration of unrestrained TASK-3 (TASK-3(-/-)) and TASK-1/TASK-3 double knockout (TASK-1/3(-/-)) adult male mice in vivo using a plethysmographic device. Ventilation parameters of TASK-3/mice were normal under control ...


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