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BIK is involved in BRAF/MEK inhibitor induced apoptosis in melanoma cell lines

Borst, Andreas, Haferkamp, Sebastian, Grimm, Johannes, Rösch, Manuel, Zhu, Guannan, Guo, Sen, Li, Chunying, Gao, Tianwen, Meierjohann, Svenja, Schrama, David and Houben, Roland (2017) BIK is involved in BRAF/MEK inhibitor induced apoptosis in melanoma cell lines. Cancer Letters 404, pp. 70-78.

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Other URL: http://doi.org/10.1016/j.canlet.2017.07.005


Abstract

In patients with BRAF-mutated melanoma specific inhibitors of BRAF(V600E) and MEK1/2 frequently induce initial tumor reduction, frequently followed by relapse. As demonstrated previously, BRAF(V600E) -inhibition induces apoptosis only in a fraction of treated cells, while the remaining arrest and survive providing a source or a niche for relapse. To identify factors contributing to the ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Dermatologie und Venerologie
Identification Number:
ValueType
10.1016/j.canlet.2017.07.005DOI
Keywords:BREAST-CANCER CELLS; HISTONE DEACETYLASE INHIBITORS; ENDOPLASMIC-RETICULUM BIK; POTENT ANTITUMOR-ACTIVITY; BCL-2 FAMILY-MEMBERS; PHASE-II TRIAL; BH3-ONLY PROTEIN; METASTATIC MELANOMA; MULTIPLE-MYELOMA; MEK INHIBITION; Melanoma; Vemurafenib; Trametinib; BIK/NBK; Apoptosis
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39768
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