Serotonin and tryptophan metabolites, autoantibodies and gut microbiome in APECED

URN to cite this document:: urn:nbn:de:bvb:355-epub-397820
DOI to cite this document:: 10.5283/epub.39782

Naskali, E. ; Dettmer, Katja ; Oefner, Peter J. ; Pereira, P. A. B.

; Krohn, K. ; Auvinen, P.

; Ranki, A. ; Kluger, N.

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Date of publication of this fulltext: 26 Mar 2019 06:47

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Abstract

Objective: Intestinal autoimmunity with gastrointestinal (GI) dysfunction has been shown in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Patients lack entero-endocrine (EE) cells and have circulating autoantibodies (Aabs) against critical enzymes in serotonin (5-HT) biosynthesis. Design: We sought to determine the serum levels of 5-HT, tryptophan (Trp) ...