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Serotonin and tryptophan metabolites, autoantibodies and gut microbiome in APECED

URN to cite this document:
urn:nbn:de:bvb:355-epub-397820
Naskali, E. ; Dettmer, Katja ; Oefner, Peter J. ; Pereira, P. A. B. ; Krohn, K. ; Auvinen, P. ; Ranki, A. ; Kluger, N.
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Date of publication of this fulltext: 26 Mar 2019 06:47


Abstract

Objective Intestinal autoimmunity with gastrointestinal (GI) dysfunction has been shown in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Patients lack entero-endocrine (EE) cells and have circulating autoantibodies (Aabs) against critical enzymes in serotonin (5-HT) biosynthesis. Design We sought to determine the serum levels of 5-HT, tryptophan (Trp) ...

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