Serotonin and tryptophan metabolites, autoantibodies and gut microbiome in APECED

URN to cite this document:: urn:nbn:de:bvb:355-epub-397820

Naskali, E. ; Dettmer, Katja

; Oefner, Peter J.

; Pereira, P. A. B. ; Krohn, K. ; Auvinen, P. ; Ranki, A. ; Kluger, N.

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Date of publication of this fulltext: 26 Mar 2019 06:47

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Abstract

Objective Intestinal autoimmunity with gastrointestinal (GI) dysfunction has been shown in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Patients lack entero-endocrine (EE) cells and have circulating autoantibodies (Aabs) against critical enzymes in serotonin (5-HT) biosynthesis. Design We sought to determine the serum levels of 5-HT, tryptophan (Trp) ...