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Serotonin and tryptophan metabolites, autoantibodies and gut microbiome in APECED

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Naskali, E. ; Dettmer, Katja ; Oefner, Peter J. ; Pereira, P. A. B. ; Krohn, K. ; Auvinen, P. ; Ranki, A. ; Kluger, N.
License: Creative Commons: Attribution-Noncommercial 3.0
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Date of publication of this fulltext: 26 Mar 2019 06:47


Objective: Intestinal autoimmunity with gastrointestinal (GI) dysfunction has been shown in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Patients lack entero-endocrine (EE) cells and have circulating autoantibodies (Aabs) against critical enzymes in serotonin (5-HT) biosynthesis. Design: We sought to determine the serum levels of 5-HT, tryptophan (Trp) ...


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