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Synthesis of substituted pyrimidine hydrazine acids (PHA) and their use in peptide recognition

Miltschitzky, Stefan ; Michlova, Veronika ; Stadlbauer, Stefan ; König, Burkhard


Substituted pyrimidine-hydrazine-acids (PHA) were prepared from orotic acid in five synthetic steps and high yields. Their geometry of hydrogen bond acceptor and donor sites make them suitable for the molecular recognition of peptide β-sheets. In non-protic solvents the PHA unit emits at around 420 nm after irradiation at 281 nm. The emission intensity decreases upon peptide binding and signals ...


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