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Synthesis of substituted pyrimidine hydrazine acids (PHA) and their use in peptide recognition

Miltschitzky, Stefan, Michlova, Veronika, Stadlbauer, Stefan and König, Burkhard (2006) Synthesis of substituted pyrimidine hydrazine acids (PHA) and their use in peptide recognition. Heterocycles 67 (1), pp. 135-160.

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Other URL: https://www2.heterocycles.jp/FMPro?-db=journalred.fp5&-format=/w2/JournalDetail.html&-lay=data&-Token.0=&-Token.3=COM-05-S(T)6&-recid=45074&-Script=citation&-find


Substituted pyrimidine-hydrazine-acids (PHA) were prepared from orotic acid in five synthetic steps and high yields. Their geometry of hydrogen bond acceptor and donor sites make them suitable for the molecular recognition of peptide β-sheets. In non-protic solvents the PHA unit emits at around 420 nm after irradiation at 281 nm. The emission intensity decreases upon peptide binding and signals ...


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Item type:Article
Date:1 January 2006
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40
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