Azologization of serotonin 5-HT3 receptor antagonists

URN to cite this document:: urn:nbn:de:bvb:355-epub-400313
DOI to cite this document:: 10.5283/epub.40031

Rustler, Karin

; Maleeva, Galyna

; Bregestovski, Piotr

; König, Burkhard

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Date of publication of this fulltext: 02 Apr 2019 13:42

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Abstract

The serotonin 5-hydroxytryptamine 3 receptor (5-HT3R) plays a unique role within the seven classes of the serotonin receptor family, as it represents the only ionotropic receptor, while the other six members are G protein-coupled receptors (GPCRs). The 5-HT3 receptor is related to chemo-/radiotherapy provoked emesis and dysfunction leads to neurodevelopmental disorders and psychopathologies. ...