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Azologization of serotonin 5-HT3 receptor antagonists

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Rustler, Karin ; Maleeva, Galyna ; Bregestovski, Piotr ; König, Burkhard
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Date of publication of this fulltext: 02 Apr 2019 13:42


The serotonin 5-hydroxytryptamine 3 receptor (5-HT3R) plays a unique role within the seven classes of the serotonin receptor family, as it represents the only ionotropic receptor, while the other six members are G protein-coupled receptors (GPCRs). The 5-HT3 receptor is related to chemo-/radiotherapy provoked emesis and dysfunction leads to neurodevelopmental disorders and psychopathologies. ...


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