Go to content
UR Home

Limitation of TCA Cycle Intermediates Represents an Oxygen-Independent Nutritional Antibacterial Effector Mechanism of Macrophages

URN to cite this document:
urn:nbn:de:bvb:355-epub-400331
Hayek, I. ; Fischer, F. ; Schulze-Luehrmann, J. ; Dettmer, Katja ; Sobotta, K. ; Schatz, V. ; Kohl, L. ; Boden, K. ; Lang, R. ; Oefner, Peter J. ; Wirtz, S. ; Jantsch, Johnathan ; Luhrmann, A.
[img]
Preview
License: Creative Commons Attribution 4.0
PDF - Published Version
(2MB)
Date of publication of this fulltext: 02 Apr 2019 13:35


Abstract

In hypoxic and inflamed tissues, oxygen (O2)-dependent antimicrobial defenses are impaired due to a shortage of O2. To gain insight into the mechanisms that control bacterial infection under hypoxic conditions, we infected macrophages with the obligate intracellular pathogen Coxiella burnetii, the causative agent of Q fever. Our experiments revealed that hypoxia impeded C. burnetii replication in ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons