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Limitation of TCA Cycle Intermediates Represents an Oxygen-Independent Nutritional Antibacterial Effector Mechanism of Macrophages

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Hayek, I. ; Fischer, F. ; Schulze-Luehrmann, J. ; Dettmer, Katja ; Sobotta, K. ; Schatz, V. ; Kohl, L. ; Boden, K. ; Lang, R. ; Oefner, Peter J. ; Wirtz, S. ; Jantsch, Jonathan ; Luhrmann, A.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 02 Apr 2019 13:35


In hypoxic and inflamed tissues, oxygen (O-2)-dependent antimicrobial defenses are impaired due to a shortage of O-2. To gain insight into the mechanisms that control bacterial infection under hypoxic conditions, we infected macrophages with the obligate intracellular pathogen Coxiella burnetii, the causative agent of Q fever. Our experiments revealed that hypoxia impeded C. burnetii replication ...


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