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Random gene sets in predicting survival of patients with hepatocellular carcinoma

Itzel, T. ; Spang, Rainer ; Maass, T. ; Munker, S. ; Roessler, S. ; Ebert, M. P. ; Schlitt, Hans J. ; Herr, Wolfgang ; Evert, Matthias ; Teufel, A.


Despite multiple publications, molecular signatures predicting the course of hepatocellular carcinoma (HCC) have not yet been integrated into clinical routine decision-making. Given the diversity of published signatures, optimal number, best combinations, and benefit of functional associations of genes in prognostic signatures remain to be defined. We investigated a vast number of randomly chosen ...


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