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TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

Kunzelmann, Karl, Ousingsawat, Jiraporn, Cabrita, Inês, Doušová, Tereza, Bähr, Andrea, Janda, Melanie, Schreiber, Rainer and Benedetto, Roberta (2019) TMEM16A in Cystic Fibrosis: Activating or Inhibiting? Frontiers in Pharmacology 10 (3), pp. 1-18.

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Date of publication of this fulltext: 03 May 2019 12:07

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Other URL: http://doi.org/10.3389/fphar.2019.00003


Abstract

The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is dysfunctional in CF, leading to defects in epithelial transport. Although CF pathogenesis is still disputed, activation of alternative Cl− channels is ...

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Item type:Article
Date:29 January 2019
Institutions:Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie II (Allgemeine und Angewandte Psychologie) - Prof. Dr. Gesine Dreisbach
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.3389/fphar.2019.00003DOI
Keywords:TMEM16A, anoctamin 1, mucus secretion, cystic fibrosis, asthma, COPD, Ca2+ signaling
Dewey Decimal Classification:100 Philosophy & psychology > 150 Psychology
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40175
Owner only: item control page

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