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TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

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Kunzelmann, Karl ; Ousingsawat, Jiraporn ; Cabrita, Inês ; Doušová, Tereza ; Bähr, Andrea ; Janda, Melanie ; Schreiber, Rainer ; Benedetto, Roberta
Date of publication of this fulltext: 03 May 2019 12:07


The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is dysfunctional in CF, leading to defects in epithelial transport. Although CF pathogenesis is still disputed, activation of alternative Cl− channels is ...


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