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Measurement of soft tissue drug concentrations in morbidly obese and non-obese patients – A prospective, parallel group, open-labeled, controlled, phase IV, single center clinical trial

Simon, P. ; Petroff, D. ; Dorn, Christoph ; Ehmann, L. ; Kloft, C. ; Prettin, C. ; Dietrich, A. ; Zeitlinger, M. ; Kees, F. ; Wrigge, H.


Background: Pharmacokinetic (PK) and pharmacodynamic (PD) data on perioperative antibiotic prophylaxis or antibiotic therapy are rare in patients suffering from morbid obesity. Furthermore, dosing regimens should be based on PK/PD models that ensure effective antibiotic exposure not in plasma, but primarily at the site of infection, mostly in the interstitial fluid (ISF). The aim of this trial is ...


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