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Isolation of Subtype 3c, 3e and 3f-Like Hepatitis E Virus Strains Stably Replicating to High Viral Loads in an Optimized Cell Culture System

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Schemmerer, Mathias ; Johne, Reimar ; Erl, Monika ; Jilg, Wolfgang ; Wenzel, Jürgen J.
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Date of publication of this fulltext: 05 Jun 2019 12:01


The hepatitis E virus (HEV) is transmitted via the faecal-oral route in developing countries (genotypes 1 and 2) or through contaminated food and blood products worldwide (genotypes 3 and 4). In Europe, HEV subtypes 3c, 3e and 3f are predominant. HEV is the leading cause of acute hepatitis globally and immunocompromised patients are particularly at risk. Because of a lack of cell culture systems ...


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