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Therapeutic targets and microenvironment in sequential biopsies of classical Hodgkin lymphoma at diagnosis and relapse

Schnitter, A., Kohler, Christian , Reddemann, K., Reinke, S., Thorns, C., Fend, F., Federmann, B., Moeller, P., Szczepanowski, Monika, Spang, Rainer and Klapper, Wolfram (2019) Therapeutic targets and microenvironment in sequential biopsies of classical Hodgkin lymphoma at diagnosis and relapse. Journal of Hematopathology 12 (1), pp. 11-17.

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Date of publication of this fulltext: 01 Jul 2019 09:07

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Other URL: https://link.springer.com/article/10.1007/s12308-019-00350-2


Abstract

Classical Hodgkin lymphoma is dominated by the non-neoplastic microenvironment, while the neoplastic Hodgkin-Reed-Sternberg cells compose only a minority of cells in the lymphoma tissue. Both the Hodgkin-Reed-Sternberg cells due to their expression of CD30 and PD-L1 and the microenvironment with abundant T cells and expression of PD1 are specifically targeted by new treatment concepts. We aimed ...

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Item type:Article
Date:March 2019
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
10.1007/s12308-019-00350-2DOI
Keywords:Hodgkin lymphoma, Microenvironment, PDL1, PD1, CD30
Dewey Decimal Classification:000 Computer science, information & general works > 004 Computer science
500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:40403
Owner only: item control page

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