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Identification of the retinoschisin-binding site on the retinal Na/K-ATPase

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Ramchandran, Ramani ; Plössl, Karolina ; Straub, Kristina ; Schmid, Verena ; Strunz, Franziska ; Wild, Jens ; Merkl, Rainer ; Weber, Bernhard H. F. ; Friedrich, Ulrike
Date of publication of this fulltext: 04 Jul 2019 04:51


X-linked juvenile retinoschisis (XLRS) is a hereditary retinal dystrophy, caused by mutations in the RS1 gene which encodes the secreted protein retinoschisin. In recent years, several molecules have been proposed to interact with retinoschisin, including the retinal Na/K-ATPase, L-voltage gated Ca2+ channels, and specific sugars. We recently showed that the retinal Na/K-ATPase consisting of ...


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