CRISPR-Cas9 Mediated TSPO Gene Knockout alters Respiration and Cellular Metabolism in Human Primary Microglia Cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-405578
DOI to cite this document:: 10.5283/epub.40557

Milenkovic, Vladimir M. ; Slim, Dounia ; Bader, Stefanie ; Koch, Victoria ; Heinl, Elena-Sofia ; Alvarez-Carbonell, David ; Nothdurfter, Caroline ; Rupprecht, Rainer ; Wetzel, Christian H.

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Date of publication of this fulltext: 23 Jul 2019 12:47

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Abstract

The 18 kDa translocator protein (TSPO) is an evolutionary conserved cholesterol binding protein localized in the outer mitochondrial membrane. It has been implicated in the regulation of various cellular processes including oxidative stress, proliferation, apoptosis, and steroid hormone biosynthesis. Since the expression of TSPO in activated microglia is upregulated in various neuroinflammatory ...