Go to content
UR Home

CRISPR-Cas9 Mediated TSPO Gene Knockout alters Respiration and Cellular Metabolism in Human Primary Microglia Cells

URN to cite this document:
urn:nbn:de:bvb:355-epub-405578
Milenkovic, Vladimir M. ; Slim, Dounia ; Bader, Stefanie ; Koch, Victoria ; Heinl, Elena-Sofia ; Alvarez-Carbonell, David ; Nothdurfter, Caroline ; Rupprecht, Rainer ; Wetzel, Christian H.
Date of publication of this fulltext: 23 Jul 2019 12:47


Abstract

The 18 kDa translocator protein (TSPO) is an evolutionary conserved cholesterol binding protein localized in the outer mitochondrial membrane. It has been implicated in the regulation of various cellular processes including oxidative stress, proliferation, apoptosis, and steroid hormone biosynthesis. Since the expression of TSPO in activated microglia is upregulated in various neuroinflammatory ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons