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CRISPR-Cas9 Mediated TSPO Gene Knockout alters Respiration and Cellular Metabolism in Human Primary Microglia Cells

Milenkovic, Vladimir M. , Slim, Dounia, Bader, Stefanie, Koch, Victoria, Heinl, Elena-Sofia, Alvarez-Carbonell, David, Nothdurfter, Caroline, Rupprecht, Rainer and Wetzel, Christian H. (2019) CRISPR-Cas9 Mediated TSPO Gene Knockout alters Respiration and Cellular Metabolism in Human Primary Microglia Cells. International Journal of Molecular Sciences 20 (13), p. 3359.

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Date of publication of this fulltext: 23 Jul 2019 12:47

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Other URL: http://doi.org/10.3390/ijms20133359


Abstract

The 18 kDa translocator protein (TSPO) is an evolutionary conserved cholesterol binding protein localized in the outer mitochondrial membrane. It has been implicated in the regulation of various cellular processes including oxidative stress, proliferation, apoptosis, and steroid hormone biosynthesis. Since the expression of TSPO in activated microglia is upregulated in various neuroinflammatory ...

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Item type:Article
Date:9 July 2019
Institutions:Medicine > Lehrstuhl für Psychiatrie und Psychotherapie > Molekulare Neurowissenscahften
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.3390/ijms20133359DOI
Keywords:TSPO; mitochondria; knockdown; knockout; mitochondrial membrane potential; Ca2+ homeostasis; oxidative phosphorylation; steroid synthesis
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40557
Owner only: item control page

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