Milenkovic, Vladimir M. 
, Slim, Dounia, Bader, Stefanie, Koch, Victoria, Heinl, Elena-Sofia, Alvarez-Carbonell, David, Nothdurfter, Caroline, Rupprecht, Rainer and Wetzel, Christian H.
(2019)
CRISPR-Cas9 Mediated TSPO Gene Knockout alters Respiration and Cellular Metabolism in Human Primary Microglia Cells.
International Journal of Molecular Sciences 20 (13), p. 3359.
| License: Creative Commons Attribution 4.0 Download (2MB) |
Other URL: http://doi.org/10.3390/ijms20133359
Abstract
The 18 kDa translocator protein (TSPO) is an evolutionary conserved cholesterol binding protein localized in the outer mitochondrial membrane. It has been implicated in the regulation of various cellular processes including oxidative stress, proliferation, apoptosis, and steroid hormone biosynthesis. Since the expression of TSPO in activated microglia is upregulated in various neuroinflammatory ...
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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 9 July 2019 | ||||
| Institutions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie > Molekulare Neurowissenscahften | ||||
| Projects: | Open Access Publizieren (DFG) | ||||
| Identification Number: |
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| Keywords: | TSPO; mitochondria; knockdown; knockout; mitochondrial membrane potential; Ca2+ homeostasis; oxidative phosphorylation; steroid synthesis | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 40557 |
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