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Topical Diclofenac Reprograms Metabolism and Immune Cell Infiltration in Actinic Keratosis

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Singer, Katrin ; Dettmer, Katja ; Unger, Petra ; Schönhammer, Gabriele ; Renner, Kathrin ; Peter, Katrin ; Siska, Peter J. ; Berneburg, Mark ; Herr, Wolfgang ; Oefner, Peter J. ; Karrer, Sigrid ; Kreutz, Marina ; Datz, Elisabeth
Date of publication of this fulltext: 24 Jul 2019 06:25


Background: Melanoma and squamous cell carcinoma of the skin are characterized by an altered glucose metabolism, but little is known about metabolic changes in precancerous skin lesions such as actinic keratosis (AK). Here, we studied the central carbon metabolism and immune cell infiltrate of actinic keratosis lesions before, under, and 4 weeks after treatment with topical diclofenac (Solaraze ...


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