Go to content
UR Home

Analysis of Allostery in the Tryptophan Synthase Complex by Horizontal and Vertical Approaches

URN to cite this document:
urn:nbn:de:bvb:355-epub-407085
DOI to cite this document:
10.5283/epub.40708
Schupfner, Michael
Date of publication of this fulltext: 19 Sep 2019 08:45


Abstract (English)

The tryptophan synthase (TS) is a linear  complex that catalyzes the last two steps of tryptophan biosynthesis in primary metabolism. It is a model system for subunit interactions in multi-enzyme complexes with a long-standing history of research. The -subunit TrpA and the -subunit TrpB display a rather low catalytic activity in isolation but strongly stimulate each other in the TS complex ...

plus

Translation of the abstract (German)

Die Tryptophan Synthase ist ein linearer abba Komplex, welcher die letzten beiden Schritte der Tryptophan Biosynthese katalysiert. In dieser Arbeit wird anhand der Modellsystems Tryptophan Synthase Allosterie mittels zwei unterschiedlicher Ansätze untersucht. Im ersten Teil werden mittels paarweisen Sequenzvergleichs zweier homologer rezenter TrpA Enzyme (horizontaler Ansatz) Mutationen in ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: daten@ur.de
0941 943 -5707

Contact persons