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Analysis of Allostery in the Tryptophan Synthase Complex by Horizontal and Vertical Approaches

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Schupfner, Michael
Date of publication of this fulltext: 19 Sep 2019 08:45

Abstract (English)

The tryptophan synthase (TS) is a linear  complex that catalyzes the last two steps of tryptophan biosynthesis in primary metabolism. It is a model system for subunit interactions in multi-enzyme complexes with a long-standing history of research. The -subunit TrpA and the -subunit TrpB display a rather low catalytic activity in isolation but strongly stimulate each other in the TS complex ...


Translation of the abstract (German)

Die Tryptophan Synthase ist ein linearer abba Komplex, welcher die letzten beiden Schritte der Tryptophan Biosynthese katalysiert. In dieser Arbeit wird anhand der Modellsystems Tryptophan Synthase Allosterie mittels zwei unterschiedlicher Ansätze untersucht. Im ersten Teil werden mittels paarweisen Sequenzvergleichs zweier homologer rezenter TrpA Enzyme (horizontaler Ansatz) Mutationen in ...


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