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Schoisswohl, Stefan ; Agrawal, Kushal ; Simoes, Jorge ; Neff, Patrick ; Schlee, Winfried ; Langguth, Berthold ; Schecklmann, Martin

RTMS parameters in tinnitus trials: a systematic review

Schoisswohl, Stefan , Agrawal, Kushal , Simoes, Jorge, Neff, Patrick, Schlee, Winfried, Langguth, Berthold und Schecklmann, Martin (2019) RTMS parameters in tinnitus trials: a systematic review. Scientific Reports 9 (12190), S. 1-11.

Veröffentlichungsdatum dieses Volltextes: 18 Sep 2019 10:20
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.40718


Zusammenfassung

Over the past few years extensive body of research was produced investigating the effects of repetitive transcranial magnetic stimulation (rTMS) for the treatment of chronic tinnitus with heterogeneous results. This heterogeneity is exemplified by two recently published large-scale clinical trials reporting different outcomes. Technical aspects of rTMS were suspected as a potential source for ...

Over the past few years extensive body of research was produced investigating the effects of repetitive transcranial magnetic stimulation (rTMS) for the treatment of chronic tinnitus with heterogeneous results. This heterogeneity is exemplified by two recently published large-scale clinical trials reporting different outcomes. Technical aspects of rTMS were suspected as a potential source for this incongruency. The aim of this systematic review is to examine the overall efficacy as well as to identify possible technical factors relevant for the effectiveness of rTMS tinnitus trials. Via a literature search appropriate original research papers were identified and rTMS parameters were extracted from each study arm for subsequent statistical analysis with respect to observed effects (significant vs. not significant pre-post rTMS effects). Our findings indicate that verum rTMS is superior to sham rTMS as demonstrated by the proportion of significant pre-post contrasts. Some relevant rTMS parameters (e.g., pulse waveform) are not reported. Lower rTMS stimulation intensity was associated with significant effects in verum rTMS arms. An additional stimulation of the DLPFC to the temporal cortex was not found to promote efficacy. Future research should consider differential effects of rTMS induced by technical parameters and strive for an exhaustive reporting of relevant rTMS parameters.



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Details

DokumentenartArtikel
Titel eines Journals oder einer ZeitschriftScientific Reports
Verlag:Nature
Ort der Veröffentlichung:LONDON
Band:9
Nummer des Zeitschriftenheftes oder des Kapitels:12190
Seitenbereich:S. 1-11
Datum21 August 2019
InstitutionenMedizin > Lehrstuhl für Psychiatrie und Psychotherapie
Identifikationsnummer
WertTyp
10.1038/s41598-019-48750-9DOI
Stichwörter / KeywordsTRANSCRANIAL MAGNETIC STIMULATION; THETA-BURST STIMULATION; AUDITORY-CORTEX; TEMPOROPARIETAL JUNCTION; BRAIN-STIMULATION; DOUBLE-BLIND; TREATMENT OUTCOMES; EFFICACY; COIL; DEPRESSION;
Dewey-Dezimal-Klassifikation600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
StatusVeröffentlicht
BegutachtetJa, diese Version wurde begutachtet
An der Universität Regensburg entstandenJa
URN der UB Regensburgurn:nbn:de:bvb:355-epub-407180
Dokumenten-ID40718

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