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Schoisswohl, Stefan ; Agrawal, Kushal ; Simoes, Jorge ; Neff, Patrick ; Schlee, Winfried ; Langguth, Berthold ; Schecklmann, Martin

RTMS parameters in tinnitus trials: a systematic review

Schoisswohl, Stefan , Agrawal, Kushal , Simoes, Jorge, Neff, Patrick, Schlee, Winfried, Langguth, Berthold and Schecklmann, Martin (2019) RTMS parameters in tinnitus trials: a systematic review. Scientific Reports 9 (12190), pp. 1-11.

Date of publication of this fulltext: 18 Sep 2019 10:20
Article
DOI to cite this document: 10.5283/epub.40718


Abstract

Over the past few years extensive body of research was produced investigating the effects of repetitive transcranial magnetic stimulation (rTMS) for the treatment of chronic tinnitus with heterogeneous results. This heterogeneity is exemplified by two recently published large-scale clinical trials reporting different outcomes. Technical aspects of rTMS were suspected as a potential source for ...

Over the past few years extensive body of research was produced investigating the effects of repetitive transcranial magnetic stimulation (rTMS) for the treatment of chronic tinnitus with heterogeneous results. This heterogeneity is exemplified by two recently published large-scale clinical trials reporting different outcomes. Technical aspects of rTMS were suspected as a potential source for this incongruency. The aim of this systematic review is to examine the overall efficacy as well as to identify possible technical factors relevant for the effectiveness of rTMS tinnitus trials. Via a literature search appropriate original research papers were identified and rTMS parameters were extracted from each study arm for subsequent statistical analysis with respect to observed effects (significant vs. not significant pre-post rTMS effects). Our findings indicate that verum rTMS is superior to sham rTMS as demonstrated by the proportion of significant pre-post contrasts. Some relevant rTMS parameters (e.g., pulse waveform) are not reported. Lower rTMS stimulation intensity was associated with significant effects in verum rTMS arms. An additional stimulation of the DLPFC to the temporal cortex was not found to promote efficacy. Future research should consider differential effects of rTMS induced by technical parameters and strive for an exhaustive reporting of relevant rTMS parameters.



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Details

Item typeArticle
Journal or Publication TitleScientific Reports
Publisher:Nature
Open Access Type:Gold (with APC)
Place of Publication:LONDON
Volume:9
Number of Issue or Book Chapter:12190
Page Range:pp. 1-11
Date21 August 2019
InstitutionsMedicine > Lehrstuhl für Psychiatrie und Psychotherapie
Identification Number
ValueType
10.1038/s41598-019-48750-9DOI
KeywordsTRANSCRANIAL MAGNETIC STIMULATION; THETA-BURST STIMULATION; AUDITORY-CORTEX; TEMPOROPARIETAL JUNCTION; BRAIN-STIMULATION; DOUBLE-BLIND; TREATMENT OUTCOMES; EFFICACY; COIL; DEPRESSION;
Dewey Decimal Classification600 Technology > 610 Medical sciences Medicine
StatusPublished
RefereedYes, this version has been refereed
Created at the University of RegensburgYes
URN of the UB Regensburgurn:nbn:de:bvb:355-epub-407180
Item ID40718

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