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Quantification and 13C-Tracer analysis of total reduced glutathione by HPLC-QTOFMS/MS

Sun, Xueni ; Heinrich, Paul ; Berger, Raffaela ; Oefner, Peter J. ; Dettmer, Katja



Abstract

Glutathione is an essential intra- and extracellular antioxidant. The level of glutathione in the body is highly related to different disease states and is a useful indicator of disease risk and oxidative stress status. We have developed a sensitive, selective, and comprehensive LC-MS/MS method for the absolute quantification and C-13-tracer analysis of total glutathione using dithiothreitol for ...

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