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Topical Diclofenac Reprograms Metabolism and Immune Cell Infiltration in Actinic Keratosis

Singer, Katrin, Dettmer, Katja , Unger, Petra, Schoenhammer, Gabriele, Renner, Kathrin, Peter, Katrin, Siska, Peter J., Berneburg, Mark , Herr, Wolfgang, Oefner, Peter J. , Karrer, Sigrid, Kreutz, Marina and Datz, Elisabeth (2019) Topical Diclofenac Reprograms Metabolism and Immune Cell Infiltration in Actinic Keratosis. Front Oncol 9, p. 605.

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Date of publication of this fulltext: 17 Oct 2019 08:54

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Other URL: https://www.frontiersin.org/articles/10.3389/fonc.2019.00605/full


Abstract

Background: Melanoma and squamous cell carcinoma of the skin are characterized by an altered glucose metabolism, but little is known about metabolic changes in precancerous skin lesions such as actinic keratosis (AK). Here, we studied the central carbon metabolism and immune cell infiltrate of actinic keratosis lesions before, under, and 4 weeks after treatment with topical diclofenac ...

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Item type:Article
Date:3 July 2019
Institutions:Medicine > Lehrstuhl für Dermatologie und Venerologie
Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Medicine > Regensburger Centrum für Interventionelle Immunologie (RCI)
Identification Number:
ValueType
31334125PubMed ID
10.3389/fonc.2019.00605DOI
Keywords:CD1a; CD8; actinic keratosis; diclofenac; lactate; metabolism
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40837
Owner only: item control page

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