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Mitochondrial DNA copy number is associated with mortality and infections in a large cohort of patients with chronic kidney disease

Fazzini, F. ; Lamina, C. ; Fendt, L. ; Schultheiss, U. T. ; Kotsis, F. ; Hicks, A. A. ; Meiselbach, H. ; Weissensteiner, H. ; Forer, L. ; Krane, V. ; Eckardt, K. U. ; Köttgen, Anna ; Kronenberg, F. ; Eckardt, K. U. ; Meiselbach, H. ; Schneider, M. ; Dienemann, T. ; Prokosch, H. U. ; Barthlein, B. ; Beck, A. ; Ganslandt, T. ; Reis, A. ; Ekici, A. B. ; Avendano, S. ; Becker-Grosspitsch, D. ; Alberth-Schmidt, U. ; Hausknecht, B. ; Zitzmann, R. ; Weigel, A. ; Walz, G. ; Kottgen, A. ; Schultheiss, U. ; Kotsis, F. ; Meder, S. ; Mitsch, E. ; Reinhard, U. ; Floege, J. ; Schlieper, G. ; Saritas, T. ; Ernst, S. ; Beaujean, N. ; Schaeffner, E. ; Baid-Agrawal, S. ; Theisen, K. ; Haller, H. ; Menne, J. ; Zeier, M. ; Sommerer, C. ; Woitke, R. ; Wolf, G. ; Busch, M. ; Fuss, R. ; Sitter, T. ; Blank, C. ; Wanner, C. ; Krane, V. ; Borner-Klein, A. ; Bauer, B. ; Kronenberg, F. ; Raschenberger, J. ; Kollerits, B. ; Forer, L. ; Schonherr, S. ; Weissensteiner, H. ; Oefner, Peter J. ; Gronwald, Wolfram ; Zacharias, Helena ; Schmid, M. ; Nadal, J.



Abstract

Damage of mitochondrial DNA (mtDNA) with reduction in copy number has been proposed as a biomarker for mitochondrial dysfunction and oxidative stress. Chronic kidney disease (CKD) is associated with increased mortality and risk of cardiovascular disease, but the underlying mechanisms remain incompletely understood. Here we investigated the prognostic role of mtDNA copy number for cause-specific ...

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