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Mitochondrial DNA copy number is associated with mortality and infections in a large cohort of patients with chronic kidney disease

Fazzini, F., Lamina, C., Fendt, L., Schultheiss, U. T., Kotsis, F., Hicks, A. A., Meiselbach, H., Weissensteiner, H., Forer, L., Krane, V., Eckardt, K. U., Kottgen, A., Kronenberg, F., Eckardt, K. U., Meiselbach, H., Schneider, M., Dienemann, T., Prokosch, H. U., Barthlein, B., Beck, A., Ganslandt, T., Reis, A., Ekici, A. B., Avendano, S., Becker-Grosspitsch, D., Alberth-Schmidt, U., Hausknecht, B., Zitzmann, R., Weigel, A., Walz, G., Kottgen, A., Schultheiss, U., Kotsis, F., Meder, S., Mitsch, E., Reinhard, U., Floege, J., Schlieper, G., Saritas, T., Ernst, S., Beaujean, N., Schaeffner, E., Baid-Agrawal, S., Theisen, K., Haller, H., Menne, J., Zeier, M., Sommerer, C., Woitke, R., Wolf, G., Busch, M., Fuss, R., Sitter, T., Blank, C., Wanner, C., Krane, V., Borner-Klein, A., Bauer, B., Kronenberg, F., Raschenberger, J., Kollerits, B., Forer, L., Schonherr, S., Weissensteiner, H., Oefner, Peter J. , Gronwald, Wolfram , Zacharias, Helena , Schmid, M. and Nadal, J. (2019) Mitochondrial DNA copy number is associated with mortality and infections in a large cohort of patients with chronic kidney disease. Kidney Int. 96 (2), pp. 480-488.

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Abstract

Damage of mitochondrial DNA (mtDNA) with reduction in copy number has been proposed as a biomarker for mitochondrial dysfunction and oxidative stress. Chronic kidney disease (CKD) is associated with increased mortality and risk of cardiovascular disease, but the underlying mechanisms remain incompletely understood. Here we investigated the prognostic role of mtDNA copy number for cause-specific ...

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Item type:Article
Date:August 2019
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
31248648PubMed ID
10.1016/j.kint.2019.04.021DOI
Keywords:chronic kidney disease; infections; mitochondrial DNA copy number; mortality
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:40850
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