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Automated macrophage counting in DLBCL tissue samples: a ROF filter based approach

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Wagner, M. ; Hansel, R. ; Reinke, S. ; Richter, J. ; Altenbuchinger, Michael ; Braumann, U. D. ; Spang, Rainer ; Loffler, M. ; Klapper, W.
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Date of publication of this fulltext: 21 Oct 2019 07:27


BackgroundFor analysis of the tumor microenvironment in diffuse large B-cell lymphoma (DLBCL) tissue samples, it is desirable to obtain information about counts and distribution of different macrophage subtypes. Until now, macrophage counts are mostly inferred from gene expression analysis of whole tissue sections, providing only indirect information. Direct analysis of immunohistochemically ...


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