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A novel lymphoma-associated macrophage interaction signature (LAMIS) provides robust risk prognostication in diffuse large B-cell lymphoma clinical trial cohorts of the DSHNHL

Staiger, A. M. ; Altenbuchinger, Michael ; Ziepert, M. ; Kohler, Christian ; Horn, H. ; Huttner, Michael ; Huttl, K. S. ; Glehr, Gunther ; Klapper, W. ; Szczepanowski, M. ; Richter, J. ; Stein, H. ; Feller, A. C. ; Moller, P. ; Hansmann, M. L. ; Poeschel, V. ; Held, G. ; Loeffler, M. ; Schmitz, N. ; Trumper, L. ; Pukrop, T. ; Rosenwald, A. ; Ott, G. ; Spang, Rainer ; Emed Demonstrator Project, ; German High Grade Non-Hodgkin’s Lymphoma Study Group (DSHNHL),



Zusammenfassung

Diffuse large B-cell lymphoma (DLBCL) is a disease with heterogeneous outcome. Stromal signatures have been correlated to survival in DLBCL. Their use, however, is hampered by the lack of assays for formalin-fixed paraffin-embedded material (FFPE). We constructed a lymphoma-associated macrophage interaction signature (LAMIS) interrogating features of the microenvironment using a NanoString assay ...

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