Inherent Grading Characteristics of Individual Pathologists Contribute to Clinically and Prognostically Relevant Interobserver Discordance Concerning Broders' Grading of Penile Squamous Cell Carcinomas

URN to cite this document:

urn:nbn:de:bvb:355-epub-408797 Copy

DOI to cite this document:

10.5283/epub.40879 Copy

Gunia, Sven ; Burger, Maximilian ; Hakenberg, O. W. ; May, D. ; Koch, S. ; Jain, A. ; Birnkammer, K. ; Wieland, W. F. ; Otto, Wolfgang ; Hofstädter, Ferdinand ; Fritsche, H.-M. ; Denzinger, S. ; Gilfrich, C. ; Brookman-May, S. ; May, Matthias

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Date of publication of this fulltext: 21 Oct 2019 14:19

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Details

Item type:	Article
Open Access Type:	Alliance-/National licence
Journal or Publication Title:	Urologia Internationalis
Publisher:	Karger
Volume:	90
Page Range:	pp. 207-213
Date:	2013
Additional Information (public):	OA-Komponente aus Allianzlizenz
Institutions:	Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Urologie
Identification Number:	Value Type 10.1159/000342639 DOI
Keywords:	Penile squamous cell carcinoma, Broders’ grading system, Interobserver reproducibility, Prognostic evaluation
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	40879

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Abstract

Introduction: The aim of our study was to evaluate the significance of transurethral resection of the prostate (TURP) to detect prostate cancer (PCa). A comparison was performed of the TURP specimens of patients undergoing high-intensity focused ultrasound (HIFU) with the core biopsies. Materials and Methods: TURP before undergoing HIFU therapy was performed in 106 patients without neoadjuvant ...

Abstract

Introduction: The aim of our study was to evaluate the significance of transurethral resection of the prostate (TURP) to detect prostate cancer (PCa). A comparison was performed of the TURP specimens of patients undergoing high-intensity focused ultrasound (HIFU) with the core biopsies. Materials and Methods: TURP before undergoing HIFU therapy was performed in 106 patients without neoadjuvant treatment. The resected tissue was subjected to histopathological evaluation and compared to the histological results of transrectal prostate biopsy. Results: Cancer was detected in the resected tissue of 69 patients (65%). A positive correlation of the amount of resected tissue and detection of PCa could be demonstrated in a multivariate analysis. Conclusions: With a rate of 65% PCa detected by TURP, our data provide evidence that TURP might be suitable to detect PCa in a small group of selected patients with continuously rising PSA levels and several negative biopsies. On the other hand, these data underline/reinforce the necessity to treat the whole gland using modern treatment modalities such as HIFU and cryotherapy.

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