Inherent Grading Characteristics of Individual Pathologists Contribute to Clinically and Prognostically Relevant Interobserver Discordance Concerning Broders' Grading of Penile Squamous Cell Carcinomas

URN to cite this document:

urn:nbn:de:bvb:355-epub-408797 Copy

DOI to cite this document:

10.5283/epub.40879 Copy

Gunia, Sven ; Burger, Maximilian ; Hakenberg, O. W. ; May, D. ; Koch, S. ; Jain, A. ; Birnkammer, K. ; Wieland, W. F. ; Otto, Wolfgang ; Hofstädter, Ferdinand ; Fritsche, H.-M. ; Denzinger, S. ; Gilfrich, C. ; Brookman-May, S. ; May, Matthias

Preview

PDF - Published Version (336kB)

Date of publication of this fulltext: 21 Oct 2019 14:19

---

Alternative links to fulltext:DOIPublisher

---

---

Details

Item type:	Article
Open Access Type:	Alliance-/National licence
Journal or Publication Title:	Urologia Internationalis
Publisher:	KARGER
Place of Publication:	BASEL
Volume:	90
Page Range:	pp. 207-213
Date:	2013
Additional Information (public):	OA-Komponente aus Allianzlizenz
Institutions:	Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Urologie
Identification Number:	Value Type 10.1159/000342639 DOI
Keywords:	HISTOLOGIC GRADE; SPECIMENS; P16(INK4A); PROGNOSIS; BIOPSY; MARKER; Penile squamous cell carcinoma; Broders' grading system; Interobserver reproducibility; Prognostic evaluation
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	40879

Preview

Indexed in

Web of Science

Export bibliographical data

ASCII CitationAtomBibTeXData Cite XMLDataCite XML OAIDublin CoreDublin Core (LZV)EndNoteHTML CitationJSONJSON LDMETSMODSOPENAIREOpenAPCRDF+N-TriplesRDF+N3RDF+XMLReferReference ManagerSimple MetadataXMLopenCostxMetaDissPlus

---

Abstract

Introduction: We assessed the reproducibility and prognostic impact of the Broders' grading system (BGS) in a cohort of 147 patients with surgically treated penile squamous cell carcinomas. Materials and Methods:Conventionally stained histology slides were graded according to the BGS in two rounds by two study pathologists. Reproducibility was assessed using K statistics. Multivariable analyses ...

Abstract

Introduction: We assessed the reproducibility and prognostic impact of the Broders' grading system (BGS) in a cohort of 147 patients with surgically treated penile squamous cell carcinomas. Materials and Methods:Conventionally stained histology slides were graded according to the BGS in two rounds by two study pathologists. Reproducibility was assessed using K statistics. Multivariable analyses were calculated to predict cancer-specific survival (CSS). The 'mean grade' per pathologist per round was calculated by allocating grade points to each study case (G1-G4: 1-4 points) and dividing the sum of all grade points by the number of cases examined. Results: The BGS showed substantial interobserver variation (59-87% with kappa = 0.38-0.69) but almost perfect intraobserver reproducibility (91% with kappa = 0.86 and 96% with kappa = 0.94, respectively). The 'mean grade' per pathologist remained nearly constant in both rounds of examination (differences <= 0.05 grade points) but differed between the two pathologists (up to 0.4 grade points). In multivariable analyses, the prognostic impact of the BGS in terms of CSS was strongly pathologist-dependent. Conclusions: Clinically and prognostically relevant interobserver discordance concerning the BGS seems, at least in part, to be attributable to inherent 'aggressive' versus 'reserved' grading characteristics of individual pathologists. Copyright (C) 2012 S. Karger AG, Basel

---

---

Metadata last modified: 29 Sep 2021 07:41

Owner only: item control page

Download Statistics

Download Statistics

Download Statistics

Download Statistics

Downloads

Downloads per month over past year

Altmetric

Altmetric

Altmetric

Alternative Statistics (altmetrics)

More literature (via CORE)

More literature (via CORE)

More literature (via CORE)

More literature (via CORE)