Downregulation of the Ubiquitin-Proteasome System in Normal Colonic Macrophages and Reinduction in Inflammatory Bowel Disease

URN to cite this document:: urn:nbn:de:bvb:355-epub-408927
DOI to cite this document:: 10.5283/epub.40892

Hetzenegger, A. M. ; Seidl, M. C. ; Kosovac, K. ; Herfarth, H. ; Kellermeier, S. ; Obermeier, Florian ; Falk, Werner ; Schölmerich, Jürgen ; Rogler, Gerhard

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Date of publication of this fulltext: 23 Oct 2019 10:01

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Abstract

Background: In normal mucosa, intestinal lamina propria macrophages (IMACs) maintain tolerance against food antigens and the commensal bacterial flora. Several mechanisms have been identified that mediate tolerance. The ubiquitin-proteasome system (UPS) is a large multiprotein complex that degrades cellular proteins. As the UPS may modulate immune functions of IMACs, we performed a detailed ...