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Role of the Hepatic Parenchyma in Liver Transplant Tolerance: A Paradigm Revisited

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Benseler, Volker ; Tay, S. S. ; Bowen, D. G. ; Bertolino, P.
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Date of publication of this fulltext: 24 Oct 2019 13:38


Unlike other solid organs, liver transplants are spontaneously accepted in a wide range of animal models. In the clinic, transplanted livers also display privileged immunological properties allowing weaning of immunosuppression therapy in up to 20% of selected patients. To explain this phenomenon, many studies have focused on the role of donor-derived ‘passenger’ leukocytes that are thought to ...


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