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LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer

Blazquez, R. ; Rietkotter, E. ; Wenske, B. ; Wlochowitz, D. ; Sparrer, D. ; Vollmer, E. ; Muller, G. ; Seegerer, J. ; Sun, Xueni ; Dettmer, Katja ; Barrantes-Freer, A. ; Stange, L. ; Utpatel, K. ; Bleckmann, A. ; Treiber, H. ; Bohnenberger, H. ; Lenz, C. ; Schulz, M. ; Reimelt, C. ; Hackl, C. ; Grade, M. ; Buyuktas, D. ; Siam, L. ; Balkenhol, M. ; Stadelmann, C. ; Kube, D. ; Krahn, M. P. ; Proescholdt, M. A. ; Riemenschneider, M. J. ; Evert, M. ; Oefner, Peter J. ; Klein, C. A. ; Hanisch, U. K. ; Binder, C. ; Pukrop, Tobias



Abstract

More than half of all brain metastases show infiltrating rather than displacing growth at the macro-metastasis/brain parenchyma interface (MMPI), a finding associated with shorter survival. The Lymphoid Enhancer-binding Factor-1 (LEF1) is an epithelial-mesenchymal transition (EMT) transcription factor that is commonly overexpressed in brain-colonizing cancer cells. Here, we overexpressed LEF1 in ...

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