P53 Codon 72 (Arg72Pro) Polymorphism and Prostate Cancer Risk: Association between Disease Onset and Proline Genotype

URN to cite this document:: urn:nbn:de:bvb:355-epub-409954
DOI to cite this document:: 10.5283/epub.40995

Rogler, Anja ; Rogenhofer, M. ; Borchardt, Albert ; Lunz, Jens-Claudio ; Knoell, Antje ; Hofstädter, Ferdinand ; Tannapfel, Andrea ; Wieland, Wolf

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Date of publication of this fulltext: 06 Nov 2019 09:50

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Abstract

The tumor suppressor gene p53 plays an important role in the stress response of the cell and is mutated in 50% of all human tumors. The p53 Arg72Pro single-nucleotide polymorphism (SNP) was found to be associated with an increased risk of various malignancies. Biochemical and biological differences between the 2 polymorphic variants of wild-type P53 might lead to distinct susceptibility to HPV- ...