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P53 Codon 72 (Arg72Pro) Polymorphism and Prostate Cancer Risk: Association between Disease Onset and Proline Genotype

Rogler, Anja, Rogenhofer, M., Borchardt, Albert, Lunz, Jens-Claudio, Knoell, Antje, Hofstädter, Ferdinand, Tannapfel, Andrea and Wieland, Wolf (2011) P53 Codon 72 (Arg72Pro) Polymorphism and Prostate Cancer Risk: Association between Disease Onset and Proline Genotype. Pathobiology 78, pp. 193-200.

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Date of publication of this fulltext: 06 Nov 2019 09:50

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Other URL: https://www.karger.com/Article/Abstract/326767


Abstract

The tumor suppressor gene p53 plays an important role in the stress response of the cell and is mutated in 50% of all human tumors. The p53 Arg72Pro single-nucleotide polymorphism (SNP) was found to be associated with an increased risk of various malignancies. Biochemical and biological differences between the 2 polymorphic variants of wild-type P53 might lead to distinct susceptibility to HPV- ...

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Item type:Article
Date:2011
Additional Information (public):OA-Komponente aus Allianzlizenz
Institutions:Medicine > Lehrstuhl für Pathologie
Medicine > Lehrstuhl für Urologie
Identification Number:
ValueType
10.1159/000326767DOI
Keywords:p53, Prostate cancer, Single-nucleotide polymorphism, Restriction fragment length polymorphism
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40995
Owner only: item control page

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