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11-β hydroxysteroid type 1 knockout mice display an antidepressant-like phenotype in the forced swim test

Slattery, David A., Uzunov, Doncho P. and Cryan, John F. (2016) 11-β hydroxysteroid type 1 knockout mice display an antidepressant-like phenotype in the forced swim test. Acta Neuropsychiatrica 28, pp. 55-60.

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Other URL: https://www.cambridge.org/core/journals/acta-neuropsychiatrica/article/11-hydroxysteroid-type-1-knockout-mice-display-an-antidepressantlike-phenotype-in-the-forced-swim-test/531703819E1FBECD6BA384587C9931CA


Abstract

Objective 11β-dehydroxysteroid dehydrogenase (HSD) types 1 and 2, enzymes are involved in the activation and inactivation of glucocorticoids in vivo, respectively. Indirect evidence implicates two enzymes in the aetiology of depression but no study has directly assessed the potential role of 11 β-HSD1 in animal tests. Methods We assessed 11 β-HSD1 knockout mice in the forced swim test (FST), ...

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Item type:Article
Date:2016
Additional Information (public):OA-Komponente aus Allianzlizenz
Institutions:Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann)
Identification Number:
ValueType
10.1017/neu.2015.50DOI
Keywords:corticosterone; knockout; mouse; 11β- dehydroxysteroid dehydrogenase
Dewey Decimal Classification:500 Science > 590 Zoological sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:41058
Owner only: item control page

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