11-β hydroxysteroid type 1 knockout mice display an antidepressant-like phenotype in the forced swim test

URN to cite this document:: urn:nbn:de:bvb:355-epub-410580
DOI to cite this document:: 10.5283/epub.41058

Slattery, David A. ; Uzunov, Doncho P. ; Cryan, John F.

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Date of publication of this fulltext: 20 Nov 2019 13:55

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Abstract

Objective 11-dehydroxysteroid dehydrogenase (HSD) types 1 and 2, enzymes are involved in the activation and inactivation of glucocorticoids in vivo, respectively. Indirect evidence implicates two enzymes in the aetiology of depression but no study has directly assessed the potential role of 11 -HSD1 in animal tests. Methods We assessed 11 -HSD1 knockout mice in the forced swim test (FST), tail ...