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Low pH reduces the activity of ceftolozane/tazobactam in human urine, but confirms current breakpoints for urinary tract infections

Nussbaumer-Pröll, Alina Karoline ; Eberl, Sabine ; Reiter, Birgit ; Stimpfl, Thomas ; Dorn, Christoph ; Zeitlinger, Markus


BACKGROUND: Acidic pH has been shown to impact the antibiotic activity of non-β-lactams in urine. OBJECTIVES: To investigate the in vitro activity of ceftolozane/tazobactam compared with meropenem at different pH settings in urine. METHODS: We determined the MICs for 30 clinical isolates of Escherichia coli, 25 clinical isolates of Klebsiella pneumoniae and 24 clinical isolates of Proteus ...


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