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Overexpression of Hepatocyte Chemerin-156 Lowers Tumor Burden in a Murine Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma

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Haberl, Elisabeth M. ; Pohl, Rebekka ; Rein-Fischboeck, Lisa ; Feder, Susanne ; Bruckmann, Astrid ; Höring, Marcus ; Krautbauer, Sabrina ; Liebisch, Gerhard ; Buechler, Christa ; ,
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 05 Feb 2020 14:50


The tumor inhibitory potential of the highly active chemerin-156 isoform was described in orthotopic models of hepatocellular carcinoma (HCC). The majority of HCC arises in the fibrotic liver, which was not reproduced in these studies. Here, a potential therapeutic activity of chemerin-156 was evaluated in diethylnitrosamine (DEN)-induced liver cancer, which mimics fibrosis-associated HCC. Mice ...


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