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Development and application of analytical tools to study the origin, fate and impact of the oncometabolite 2-hydroxyglutarate and its lactone

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Berger, Raffaela Sarah
Date of publication of this fulltext: 06 Feb 2020 09:02

Abstract (English)

This thesis investigated the impact and metabolism of the known oncometabolite D 2 hydroxyglutarate and its recently recognized lactone R-5-oxo-2-tetrahydro-furancarboxylic acid. Production and biological effects of 2 hydoxyglutarate are well described in the literature. However, accumulation of this metabolite as a result of insufficient degradation was studied for the first time in this thesis. ...


Translation of the abstract (German)

Diese Arbeit untersuchte die Auswirkungen und den Stoffwechsel von Onko-Metaboliten am Beispiel von D-2-Hydroxyglutarat und seinem Lacton, R-5-Oxo-2-tetrahydrofurancarbonsäure mit Hilfe einiger bioanalytischer Methoden. Die Produktion und die biologischen Effekte von 2 Hydroxyglutarat sind in der Literatur gut beschrieben. Im Gegensatz dazu wurde in dieser Dissertation die Akkumulation dieses ...


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