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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-415179
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.41517
Zusammenfassung
HER2 positive JIMT-1 breast tumors are resistant to trastuzumab treatment in vitro and develop resistance to trastuzumab in vivo in SCID mice. We explored whether these resistant tumors could still be eliminated by T cells redirected by a second-generation chimeric antigen receptor (CAR) containing a CD28 costimulatory domain and targeting HER2 with a trastuzumab-derived scFv. In vitro, T cells ...
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