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Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation

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Da Pozzo, E. ; Tremolanti, C. ; Costa, B. ; Milenkovic, Vladimir M. ; Bader, Stefanie ; Wetzel, Christian H. ; Rupprecht, Rainer
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 07 Feb 2020 10:51


A key role of the mitochondrial Translocator Protein 18 KDa (TSPO) in neuroinflammation has been recently proposed. However, little is known about TSPO-activated pathways underlying the modulation of reactive microglia. In the present work, the TSPO activation was explored in an in vitro human primary microglia model (immortalized C20 cells) under inflammatory stimulus. Two different approaches ...


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