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Cell-Type-Specific Complement Expression in the Healthy and Diseased Retina

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Pauly, Diana ; Agarwal, Divyansh ; Dana, Nicholas ; Schäfer, Nicole ; Biberger, Josef ; Wunderlich, Kirsten A. ; Jabri, Yassin ; Straub, Tobias ; Zhang, Nancy R. ; Gautam, Avneesh K. ; Weber, Bernhard H.F. ; Hauck, Stefanie M. ; Kim, Mijin ; Curcio, Christine A. ; Stambolian, Dwight ; Li, Mingyao ; Grosche, Antje
Date of publication of this fulltext: 07 Feb 2020 16:33


Complement dysregulation is a feature of many retinal diseases, yet mechanistic understanding at the cellular level is limited. Given this knowledge gap about which retinal cells express complement, we performed single-cell RNA sequencing on ∼92,000 mouse retinal cells and validated our results in five major purified retinal cell types. We found evidence for a distributed cell-type-specific ...


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