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Sensory Neuropeptides and their Receptors Participate in Mechano-Regulation of Murine Macrophages

Muschter, Dominique ; Beiderbeck, Anna-Sophie ; Späth, Tanja ; Kirschneck, Christian ; Schröder, Agnes ; Grässel, Susanne


This study aimed to analyze if the sensory neuropeptide SP (SP) and the neurokinin receptor 1 (NK1R) are involved in macrophage mechano-transduction, similar to chondrocytes, and if alpha-calcitonin gene-related peptide (CGRP) and the CGRP receptor (CRLR/Ramp1) show comparable activity. Murine RAW264.7 macrophages were subjected to a cyclic stretch for 1-3 days and 4 h/day. Loading and ...


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