DNA-catalyzed Henry Reaction in Pure Water and the Striking Influence of Organic Buffer Systems

URN to cite this document:: urn:nbn:de:bvb:355-epub-415682
DOI to cite this document:: 10.5283/epub.41568

Häring, Marleen ; Pérez-Madrigal, Maria M.

; Kühbeck, Dennis ; Pettignano, Asja ; Quignard, Françoise ; Diaz Diaz, David

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Date of publication of this fulltext: 12 Feb 2020 13:14

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Abstract

In this manuscript we report a critical evaluation of the ability of natural DNA to mediate the nitroaldol (Henry) reaction at physiological temperature in pure water. Under these conditions, no background reaction took place (i.e., control experiment without DNA). Both heteroaromatic aldehydes (e.g., 2-pyridinecarboxaldehyde) and aromatic aldehydes bearing strong or moderate electron-withdrawing ...