HDAC3 is essential for Human Leukemic Cell Growth and the Expression of β-catenin, MYC, and WT1

URN to cite this document:: urn:nbn:de:bvb:355-epub-415751
DOI to cite this document:: 10.5283/epub.41575

Beyer, M. ; Romanski, A. ; Mustafa, Al-Hassan M. ; Sellmer, Andreas

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Date of publication of this fulltext: 13 Feb 2020 08:55

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Abstract

Therapy of acute myeloid leukemia (AML) is unsatisfactory. Histone deacetylase inhibitors (HDACi) are active against leukemic cells in vitro and in vivo. Clinical data suggest further testing of such epigenetic drugs and to identify mechanisms and markers for their efficacy. Primary and permanent AML cells were screened for viability, replication stress/DNA damage, and regrowth capacities after ...