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CCR7 Is Important for Mesangial Cell Physiology and Repair

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Wurm, Simone ; Steege, Andreas ; Rom-Jurek, Eva-Maria ; van Roeyen, C. R. ; Kurtz, Armin ; Banas, Bernhard ; Banas, Miriam C.
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Date of publication of this fulltext: 02 Mar 2020 14:37


The homeostatic chemokine receptor CCR7 serves as key molecule in lymphocyte homing into secondary lymphoid tissues. Previous experiments from our group identified CCR7 also to be expressed by human mesangial cells. Exposing cultured human mesangial cells to the receptor ligand CCL21 revealed a positive effect on these cells regarding proliferation, migration, and survival. In the present study, ...


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